Pięć rozwijające Etapy policystycznych choroby nerek (PKD)

Wielotorbielowatość nerek jest genetyczną nerek, które charakteryzuje się skupisk wypełnionych płynem pęcherzyków po obu stronach w nerkach. Torbiele mogą się powiększyć w okresach czasu, w procesie tym pacjenci mogą doświadczyć krwiomocz, białkomocz, wysokie ciśnienie krwi, itp. Początek PKD jest zwykle na swoich 30-tych. Rozwijające etapy PKD jest wyjaśnione w tym fragmencie, tak aby pomóc Ci zrozumieć chorobę lepiej.
Istnieje pięć klinicznych rozwijających etapy policystycznych choroby nerek:
1. Okres Emergence To rodzaj choroby genetycznej, więc pacjenci mieli torbiele, kiedy się urodził, jak torbiele były małe, więc trudno być sprawdzone przed 20 lat.
2. Okres wzrostu. Torbiele wzrośnie szybko, gdy pacjenci są 30-40 lat, a w niektórych krajach zachodnich nie ma żadnych sposobów radzenia sobie z nimi, a oni myślą, że torbiele nie muszą być traktowane, jednak agresywne leczenie jest bardzo ważne, celem leczenia jest utrzymać torbiel z uprawy lub opóźnić jej prędkość rośnie, aby przedłużyć życie pacjentów za pomocą Micro-medycyny chińskiej, może promować krążenie krwi i usuwanie krwi stasis.
3. Swelling.When pacjenci są ponad 40 lat, torbiele stanie się większy, gdy torbiel jest więcej niż 4 cm więcej kliniczne objawy pojawią się, takie jak bóle pleców, białkomoczem wysoki poziom kreatyniny, podwyższone ciśnienie krwi, hematuresis itp. Ten etap jest krytyczny, jeżeli może być dobrze traktowani pacjenci nerek można odzyskać także może to spowodować niewydolność nerek szybko.
4. Burst etap. czy torbiel rośnie w jakimś przyczyny zewnętrznej będzie wybuchać, co może spowodować zakażenie i ichorrhemia oraz ostra niewydolność nerek.
5. Mocznica. Pacjenci mają do wyboru dializy lub przeszczepu nerki w celu ochrony ich czynność nerek co gorsza ich czynność nerek nie można odzyskać.
Jeśli nie można PKD traktowano dobrze terminowo, to będzie dostać niewydolność nerek szybko. Dzienna opieka pielęgniarska i prawidłowe leczenie choroby jest niezbędna, aby spowolnić pogarszanie się choroby.

Jak diagnozować choroby policystycznych nerek

Przed dokonaniem diagnozy policystycznych choroby nerek, lekarze zazwyczaj zadać szereg pytań, takich jak jakie są obecne objawy i Masz PKD historię. Ponadto, pacjenci są proszeni o wykonanie fizycznego egzamin i kilka testów związanych z nerkami, w tym USG, rezonans magnetyczny (MRI), skomputeryzowany teomography Scan (TK) i badania genetyczne.
Policystycznych objawy choroby nerek pomóc lekarze mają ogólnej diagnozy na temat tej choroby. PKD przynosi im różne objawy w innym etapie, więc ucząc ich objawów, lekarze będą mieć ogólną wiedzę na temat ich obecnego stanu choroby.
Diagnozowanie choroby policystycznych nerek przez jej objawów
W ogóle, PKD pacjenci cierpią żadnych objawów na samym początku. PKD jest chorobą dziedziczną, czyli większości chorych rodzą się z PKD genu. PKD gen leży w 16. chromosomie komórki nabłonka kanalików nerkowych. Przed torbiele w PKD pojawiają się i uszkodzenie tkanki nerek, chorzy zazwyczaj nie czuję nic innego i mogą żyć tak swobodnie, jak im się podoba. W takim przypadku, nie może mieć żadnych uszkodzeń nerek lub po prostu łagodne uszkodzenia nerek.
Ponieważ coraz więcej cysty pojawiają się w nerkach, PKD pacjenci będą cierpieć różne objawy, takie jak bóle pleców, moczu krwi, moczu spienionej, wysokie ciśnienie krwi, wzrost nerek i niedokrwistość i tak dalej. Występowanie tych objawów wskazuje sprecyzowane poważne uszkodzenia nerek.
Podobnie jest z wieloma innymi chorobami nerek powiązanych, takich jak nefropatia cukrzycowa, nefropatia IgA i nefropatią nadciśnienie, choroby policystycznych nerek będzie również z pewnością rozwinie się niewydolność nerek, które muszą być traktowane z dializy lub przeszczepu nerki. Aby uniknąć takiej złe konsekwencje, zatrzymując cyst ze rozszerzającej jest kluczowy punkt.
Chociaż objawy policystycznych choroby nerek pozwala uzyskać o stanie choroby, dokładne rozpoznanie potrzeb PKD być na absis medycznych testów.
Testy medyczne zdiagnozować choroby policystycznych nerek
Ultradźwięki: Jako pierwszy wybór dla diagnozowania choroby policystycznych nerek, USG działa przekazując fal dźwiękowych przez ciało, aby stworzyć obraz nerek i cysty w nerkach. Ponadto, może on wykrywać torbieli nerek płodu.
Rezonans magnetyczny (MRI): Podobnie z USG, rezonans magnetyczny może być również stosowany do wykrywania torbieli w nerkach. Ale to jest rzadziej stosowana w diagnostyce choroby policystycznych nerek w porównaniu z USG.
Komputerowy Teomography Scan (TK): CT scan umożliwia lekarzom zobaczyć przekrojowe obrazy nerki, więc jest to także bardzo ważny test do diagnozowania Polycytic choroby nerek.
Badanie genetyczne: W odróżnieniu od powyższych testów, test genetyczny jest bardziej zaawansowany z możliwości, że wykrywając obecność mutacji PKD autosomalna dominująca przed torbiele rozwoju. Osoba, która wie o PKD mutacji genów może być w stanie zapobiec tej chorobie poprzez regulowanie diety i kontroli ciśnienia tętniczego.
General diagnoza o policystycznych choroby nerek pozwala nam ogólną wiedzę o naszym stanie choroby, ale dokładna diagnoza pozwala nam podjąć odpowiednie środki w celu zwalczania choroby policystycznych nerek. Dlatego z tej perspektywy, dokładna diagnoza o policystycznych choroby nerek jest bardziej korzystne.

Pięć rozwijające Etapy policystycznych choroby nerek (PKD)

Wielotorbielowatość nerek jest genetyczną nerek, które charakteryzuje się skupisk wypełnionych płynem pęcherzyków po obu stronach w nerkach. Torbiele mogą się powiększyć w okresach czasu, w procesie tym pacjenci mogą doświadczyć krwiomocz, białkomocz, wysokie ciśnienie krwi, itp. Początek PKD jest zwykle na swoich 30-tych. Rozwijające etapy PKD jest wyjaśnione w tym fragmencie, tak aby pomóc Ci zrozumieć chorobę lepiej.
Istnieje pięć klinicznych rozwijających etapy policystycznych choroby nerek:
1. Okres Emergence To rodzaj choroby genetycznej, więc pacjenci mieli torbiele, kiedy się urodził, jak torbiele były małe, więc trudno być sprawdzone przed 20 lat.
2. Okres wzrostu. Torbiele wzrośnie szybko, gdy pacjenci są 30-40 lat, a w niektórych krajach zachodnich nie ma żadnych sposobów radzenia sobie z nimi, a oni myślą, że torbiele nie muszą być traktowane, jednak agresywne leczenie jest bardzo ważne, celem leczenia jest utrzymać torbiel z uprawy lub opóźnić jej prędkość rośnie, aby przedłużyć życie pacjentów za pomocą Micro-medycyny chińskiej, może promować krążenie krwi i usuwanie krwi stasis.
3. Swelling.When pacjenci są ponad 40 lat, torbiele stanie się większy, gdy torbiel jest więcej niż 4 cm więcej kliniczne objawy pojawią się, takie jak bóle pleców, białkomoczem wysoki poziom kreatyniny, podwyższone ciśnienie krwi, hematuresis itp. Ten etap jest krytyczny, jeżeli może być dobrze traktowani pacjenci nerek można odzyskać także może to spowodować niewydolność nerek szybko.
4. Burst etap. czy torbiel rośnie w jakimś przyczyny zewnętrznej będzie wybuchać, co może spowodować zakażenie i ichorrhemia oraz ostra niewydolność nerek.
5. Mocznica. Pacjenci mają do wyboru dializy lub przeszczepu nerki w celu ochrony ich czynność nerek co gorsza ich czynność nerek nie można odzyskać.
Jeśli nie można PKD traktowano dobrze terminowo, to będzie dostać niewydolność nerek szybko. Dzienna opieka pielęgniarska i prawidłowe leczenie choroby jest niezbędna, aby spowolnić pogarszanie się choroby.

Diet for People with IgA Nephropathy

IgA nephropathy is a type of kidney disease.
IgA nephropathy is a kidney disorder that occurs when IgA-a protein that helps the body fight infections-settles in the kidneys. After many years, the IgA deposits may cause the kidneys to leak blood and sometimes protein in the urine.

Who is at risk for IgA nephropathy?
IgA nephropathy can occur at any age, even in childhood. More men are affected than women. Although found all over the world, IgA nephropathy is more common among Caucasians and Asians. It is one of the most common diseases of the kidney, other than those caused by diabetes or high blood pressure.

Diet for People with IgA Nephropathy
Low protein diet because protein rich foods will make the person glomeruli to function without rest thus making the kidney pressure higher.
Medical professionals recommend the patient with IgA Nephropathy to be a vegetarian. To prevent or slow the progression of kidney damage.
Diet that has low salts as well as controlling fluid intake of the person is also part of the treatment to reduce the swelling that the person is experiencing.
These foods should be avoided by the patient:
Stimulating foods such as seafood, beef and spicy foods.
Foods that stimulate the internal heat of the body like chocolate and hot pepper.
Food that is high in potassium like banana, potato and tomato.
Patients that has a high uric acid should avoid foods like fish, shrimp, and crab.

FISH OIL SUPPLEMENTS IN KIDNEY DISEASE

Ever since James Donadio, MD, published his 1999 paper about the benefits of fish oil for patients with IgA nephropathy, patients with all types of chronic kidney disease have sought more information. Donadio's paper suggested that fish oil retarded the progression of IgA nephropathy, a disease that can end in renal failure. Writing from the Mayo Clinic, Donadio's work had a blush of credibility that other claims lack. While the jury is still out, many nephrologists suggest that patients with chronic immunologically mediated kidney diseases take fish oil.
Warning
Never confuse fish oil with cod liver oil. While fish oil may be beneficial, cod liver oil can be toxic because it contains high concentrations of vitamin A. This is particularly problematic for patients with kidney damage. Packages of fish oil and cod liver oil are labeled very differently. Fish oil containers never include the phrase "cod liver oil." Kidney patients should steer clear of cod liver oil until they consult their nephrologists.
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Conflicting Results
After Donadio's paper appeared, studies in everything from rats to transplant patients examined the possible benefit of supplementation with fish oil. While many of these results look promising, studies are often small and the results are not conclusive. However, many nephrologists believe that supplementation with fish oil has no dangers, so they recommend fish oil to their patients.
Omega-3 Fatty Acids
Fish oil contains a mixture of omega-3 fatty acids. With respect to kidney disease, the important omega-3s are eicosapentanoic acid and docosahexanoic acid, which are abbreviated EPA and DHA, respectively. Although standard dosages of fish oil have never been established, many people look to the Donadio paper for guidance. Donadio's 1994 Mayo Clinic trial report involves dosing patients with 1.8 g of EPA and 1.4 g of DHA. While the EPA and DHA content of different fish oil brands varies, many patients find that 6 g of fish oil twice a day had the necessary amounts of these fatty acids.
Contra-Indications
The Foundation for IgA Nephropathy notes that fish oil can increase the anti-platelet activity of aspirin, ibuprofen and other non-steroid anti-inflammatory drugs. While you should always discuss taking any drug or supplement with your nephrologist, this is doubly important if you take aspirin regularly. Your nephrologist may be able to adjust doses so that you get the maximum possible benefit with the least possible risk

WHAT CAUSES PROTEIN IN IgA Nephropathy?

Several conditions can cause protein in your kidneys. According to the National Institute of Diabetes and Digestive and Kidney Diseases, or NIDDK, when blood passes through healthy kidneys, the kidneys filter out waste products and leave things that your body needs, such as proteins, in your blood. Most proteins are too large to pass through your kidneys' filters and into your urine. However, certain diseases, called glomerular diseases, can attack the tiny blood vessels, or glomeruli, in your kidneys, causing protein to accumulate in your kidneys and, eventually, your urine.
IgA Nephropathy
IgA nephropathy can cause protein in your kidneys and urine. The NIDDK states IgA nephropathy, also known as Berger's disease, is a kidney disorder that develops when IgA -- a protein that helps your body ward off infections -- settles in your kidneys. Over time, the IgA deposits can cause your kidneys to leak blood and protein into your urine. IgA nephropathy can occur at any age, reports the NIDDK, even in childhood. Men are more commonly affected than women, and IgA nephropathy is more likely to occur in caucasians and Asians. Along with kidney problems caused by diabetes and elevated blood pressure, IgA nephropathy is one of the most common kidney diseases. According to MayoClinic.com, common signs and symptoms associated with IgA nephropathy include protein in your kidneys and urine, cola- or tea-colored urine, flank pain, foamy-appearing urine, swelling in your hands and feet, high blood pressure and low-grade fever.

Iga nephropathy Lifestyle and home remedies

IgA nephropathy (nuh-FROP-uh-the) is a common kidney disease that occurs when an antibody called immunoglobulin A (IgA) lodges in your kidneys. This hampers your kidneys' ability to filter waste, excess water and electrolytes from your blood. Over time, IgA nephropathy — also called Berger's disease — can lead to blood and protein in your urine, high blood pressure, and swollen hands and feet.


In 1968, French nephrologist Dr. Jean Berger first described immunoglobulin A (IgA) nephropathy. Sometimes referred to as Berger’s disease, IgA nephropathy is a kidney disease that causes the kidneysto become inflamed. At first the disease was believed to be of little threat. But after more and more researchers looked into IgA nephropathy, it turned out that as many as 50 percent of the cases progressed to end stage renal disease (ESRD), or kidney failure, according to the IgA Nephropathy Support Network. After diabetes and high blood pressure, IgA nephropathy is the third leading cause of chronic kidney disease in the United States.
Immunoglobulin A is an antibody. Antibodies are produced when there is a virus, bacterium or toxin, threatening your body. Normally, these antibodies will help fight the thing that is invading your body. For reasons that are unknown, IgA can get into the kidney, causing inflammation. IgA can eventually lead to blood and protein in the urine, high blood pressure, swollen hands and feet and other signs of chronic kidney disease.


Some steps you can take on your own that may help keep your kidneys healthier include:

Some steps you can take on your own that may help keep your kidneys healthier include:
Switch to a low-salt diet. Keeping your blood pressure levels near normal may help slow kidney damage from IgA nephropathy. Your doctor may recommend changes in your diet — such as limiting your salt intake — to help manage your blood pressure. A low-salt diet can also help minimize fluid retention and swelling.
Eat less protein. Reducing the amount of protein you eat and taking steps to decrease your cholesterol levels may help slow the progression of IgA nephropathy and protect your kidneys.
Monitor your blood pressure levels at home. Write down each reading and bring this record with you to your doctor's appointments.

Note iga nephropathy treatment

iga nephropathy treatment considerations? IgA nephropathy in the name, people feel very puzzled, because patients do not know that fact, IgA is an immune protein, once its produce alienation, will be a lot of precipitation in the kidney area, resulting in kidney damage. This problem in the medical profession, there has been no conclusion However, some of the principles for the treatment of IgA nephropathy patients can understand. The following experts from our hospital as we explain:
Treatment for the cause of clear immune complexes, adjust the body is the key.
The cause of IgA nephropathy is caused by a variety of reasons, the innate immune cells of the kidney of variation and kidney count. Should take the following measures:
Try to clear immune complexes, and to prevent the immune complexes to continue deposition. In the meantime, try to make the patient's body from the upper respiratory system infection distress factors.
Second, for the treatment of the disease process, improve their immune system is the key.
Off kidney fibrosis process is of great significance for the effective control of IgA nephropathy. Lies in improving repair inherent cells, blocking the process of renal fibrosis have lost their own immunity. Only own immune system has been improved, the immune system will not have too much alienation reaction.
Third, for the treatment of symptoms, regulate the body balance is the key.
IgA in patients with clinical symptoms, mostly associated with water, electrolyte and acid-base balance; otherwise can be expressed as the amount of symptoms of nephrotic syndrome. For the treatment of the symptoms can be improved within the environment of disorder, regulate renal imbalance and improve the quality of life of patients with IgA nephropathy.
Iga nephropathy treatment considerations detailed explain, preferably by TCM systemic conditioning our hospital nephrology experts, after years of clinical practice, long combination of Chinese and Western medicine, the creation of a 3D live kidney therapy three-dimensional living renal therapy, balance the body's yin and yang to the greatest degree, stimulate the remaining functions of the kidneys.

iga nephropathy should be how care

iga nephropathy should be how to care? iga nephropathy has been plagued by people as a disease, has numerous iga nephropathy patients still suffer torture. Here biological immune treatment center experts for our simple answer.
IgA nephropathy is immune pathological diagnosis is not a single disease, but a total of
With the immune pathological features (IgA or IgA main immunoglobulin with C3 was granular deposition in the mesangial) is a group of diseases, the pathological mesangial hyperplasia. The typical clinical manifestations of asymptomatic hematuria, some accompanied by back pain and abdominal pain. The principle of treatment is rest, anti-inflammatory and symptomatic treatment. Common care issues: ① pain; ② lack of knowledge.
Pain
Relevant factors
Due to the small blood vessels in the kidney swelling stretch the capsule of the kidney and renal.
Mainly
The kidneys District dull pain, hematuria, particularly at night, and some patients with abdominal pain significantly compared with other glomerular diseases.
【Care goals]
The pain is relieved or disappeared.
Master methods of pain relief.
【Care measures]
The nature of the pain, location, intensity, duration, etc. were observed.
To explain the causes of pain.
To help patients change position to relieve pain.
Local hot or treatments.
Patients listening to music, talking with people to distraction to relieve pain.
Prescribed for analgesic efficacy and side effects.
Key evaluation
Patient pain is alleviated.
Lack of knowledge
Relevant factors
Patient feels very light or no symptoms, easily overlooked.
Unwilling to accept a kidney biopsy surgery.
Mainly
Not trust that renal biopsy surgery research needs.
【Care goals]
Patients understand the process of the development of this disease.
With the necessary diagnostic measures - Renal biopsy surgery.
【Care measures]
For the disease knowledge missionaries, provide written materials and the introduction of the latest developments at home and abroad.
Explain early diagnosis: the need for renal biopsy and preoperative and postoperative considerations.
Isolated hematuria, whether with or without proteinuria should be maintenance-based, do not fatigue, anti-cold, time to cure the infected lesions, drugs caution renal damage.
Chronic tonsillitis, acute phase after tonsillectomy can reduce kidney damage.
Regularly check blood pressure, urine and renal function.
Key evaluation
The level of awareness of the disease.
With the diagnosis and treatment of the case.
iga kidney disease should be how care? the above biological immune treatment center experts made answer. If you still care iga nephropathy do not know, you can consult our online experts, hospital online experts for your detailed answers. I wish you a speedy recovery of the body.

iga nephropathy is caused by what

iga nephropathy is one of the more serious kidney disease, this disease is due to what causes it? Let us follow the biological immune therapy center experts to look at iga nephropathy is due to what causes.
(A) causes
The cause is not very clear, with a variety of factors. Most scholars believe that this disease is to contain IgA circulating immune complexes deposited in the kidney and disease. Complex antigen may be infected with respiratory or gastrointestinal mucosa viruses, bacteria, or food ingredients.
(B) in the pathogenesis
. Pathogenesis of renal tissue of IgA, C3, and (or) IgA, IgG deposition, IgA nephropathy is an immune complex glomerulonephritis, the incidence of IgA immune disorders are closely related, the present study has depth to IgA molecular structure level.
(1) the structure and characteristics of immunoglobulin A: IgA is an important immune globulin, accounting for 15.2% of the total serum immunoglobulin, 80% of serum IgA in the form of the monomer four chain monomer The inter-connected by disulfide bonds and the stability of the J chain. By α heavy chain different antigenic IgA is divided into two serotypes, i.e., IgA1 and IgA2.
IgA1 is the main subtype in the serum, accounting for 80% ~ 90%, IgA2, only 10% to 20%. IgA1 hinge region is 1 times longer than IgA2 IgA2 can be divided into the the IgA2m (1) and the IgA2m (2), although the concentration in serum IgA2 only IgA1 1/4, but the secretion of fluid equal to the 1gA2 concentration IgA1. Structure IgA2m (1) alpha chain and light chain disulfide bonds, connected to rely on non-covalent bonds, but between the light chain and α chain disulfide bonds connected.
Another form of IgA called secretory IgA (SIgA) exist in the outer secretions, such as saliva, tears, intestinal secretions and colostrum. Secretory IgA and serotype different, it is a dimeric molecule with a J chain, and the other outer secretory component (SC), composition (IgA) 2-J-SC complexes. Serotype is (IgA) 2-J composition.
J chain consists of 137 amino acids, molecular weight of 1500, is an acidic glycoprotein containing 8 cysteine ​​residues, six with intra-chain disulfide bond formation, and the two with the connection of the α chain. 18 additional amino acid residues of the C-terminus of the known α chain, J chain is connected through the first two cysteine ​​residues with an α-chain with the C-terminus of the α chain. Both of which are produced by plasma cells, and secretion would be connected together.
SC is synthesized by the epithelial cells in the mucosal tissue or endocrine body, connected through one of the two monomer IgA disulfide colleagues SIgA, SC is from 549 to 558 amino acids of the polypeptide chain, a molecular weight of about 7 Wan, glycosyl content of up to 20%. 5 homologous region in its polypeptide chain, each of the homologous region from the 104,114 amino acids, these homologous regions in the three-dimensional structure similar to and Ig. It has been known that is connected to the α-chain in the Fc region, but the precise positioning is not yet clear. The SIgA configuration may add up to the Y-shaped arrangement: ① a heap; ② The end of the end of the arrangement, the two IgA Fc α connected double Y-shaped structure.
Local tissue plasmacytomas (IgA) 2-J through the: ① with epithelial cell surface of the substrate side of the SC combination formed IgA-J-SC, and transferred to the top surface of a vesicle and secreted; ② (IgA) 2-J lymphatic vessels into the blood circulation, SC combined with the surface of the liver cells and clear, then turn to enter the biliary vesicle mechanism of liver cells, and eventually into the intestines.
The serum IgA terminal connected to each other may be formed to open at the end of polymer, and an obvious feature is a poly body size heterogeneity, the serum IgA 20% of polymer present in the form, and the sedimentation coefficient of 10s 13s, 15s ranging addition IgA Ease of a tendency to form a complex with other proteins, which are vulnerable due to the α-chain of the amino acid residues in the formation of intermolecular disulfide bonds. IgA molecular structure of these characteristics is important in IgA nephropathy.
(2) IgA deposition in the mesangial area: IgA nephropathy, IgA deposition and glomerular pathological changes parallel. Associated with mesangial proliferative mesangial IgA deposition, deposition on the capillary accompanied by changes of the vascular endothelial.
IgA deposition caused by pathological factors: ① antigen from the mucous membrane into the body and stimulate IgA immune system, the antigen component of a wide range of microorganisms, Food (ovalbumin, bovine serum albumin, casein), etc.. ② IgA immune response abnormalities lead to high molecular weight poly-IgA formation. (3) antigen-binding poly-IgA by electrostatic (λ chain), receptor (Fear) or connected to the fiber to protein binding and deposition in the kidneys, it has been found that the serum IgA-fibronectin complex is characterized IgA nephropathy. ④ Other IgA clearance mechanisms (such as liver) damage or saturation.
Existing studies show that the deposition in the glomeruli of the IgA IgA nephropathy is mainly poly λ-IgA1, the average IgA nephropathy patients, serum IgA1, poly-IgA, λ-IgA1 water visible increased. B cells in patients with reduced end link of galactose, β-1, 3 galactosyl transferase (β-1, 3GT) defects, resulting in O-glycosylation of IgA1 hinge region, this change may affect IgA1 and oligonucleotide on the sialic acid in the liver cell receptor (ASGPR) binding affect the clearance of IgA, but also increase the combined deposition and kidney tissue.
Harpel by in situ hybridization study found that of IgA nephropathy intestinal mucosa express an essential component of the synthesis of poly-IgA J chain mRNA levels decreased, while the bone marrow is increased. In addition tonsil PIgA1 also increased. The due production of tonsil PIgA is far lower than the mucosa and bone marrow, it is deposited in the kidney tissue PIgAl mainly derived from bone marrow rather than tonsils and mucosal.
(3) IgA nephropathy immune abnormalities: IgA nephropathy humoral and cellular immune extensive research shows that patients with IgA nephropathy immune abnormalities, including:
① autoantibodies: Fornesier, has been found in the serum of kidney patients have antibodies for kidney mesangial cell cytoplasm macromolecular components. In addition to antibodies against the basement membrane Ⅰ, Ⅱ type III collagen fibers laminin, Gliadin ingredients. IgA anti-neutrophil cytoplasmic antibodies (IgA-ANCA) is also found in the blood of some patients. IgA nephropathy received renal allograft re-appear in the transplanted kidney the IgA nephropathy pathological changes by as much as 40% to 50%, these data are autoantibodies play an important role in the pathogenesis of IgA nephropathy.
② cellular immunity: studies have shown that the cellular immune function disorders are IgA nephropathy play an important role in the pathogenesis. IgA specific inhibition of the decline in the activity of T cells resulting in B lymphocytes increased synthesis of IgA. T helper cell (Th) of activity in IgA nephropathy increased activity of Th / Ts increased. IgA specific receptor of T cells referred to as a the Tα cell, Talpha cells increase the role of IgA production. It was found that IgA nephropathy, especially for patients with gross hematuria Tα increased significantly, Tα helper cells resulted in significantly increased IgA synthesis increased.
③ cell factor and inflammation of the media: many cytokines involved in the regulation of the immune system, including lymphokines White mediated hormone (interleukin, of IL), tumor necrosis factor, a polypeptide growth factor, these cytokines for the exercise of normal immune function from the important role in the abnormal circumstances will cause the offset of the cytokine network, thereby generating immune injury. Mesangial cell proliferation, cytokine and inflammatory mediators (complement components MAC, IL-1, MCP-1, reactive oxygen species, etc.) play an important role.
④ immune genetic: there are family members has suffering from IgA nephropathy reported, suggesting that genetic factors important role in IgA nephropathy. IgA nephropathy associated HLA antigen sites also reports vary, Europe and the United States Bw35, Japan and China DR4 common, also reported in northern China Han DRWl2 most common, in addition to B12, DR1 and IL-RN.2 bit gene, ACED / D genotype reported.
These sediments have diagnostic value. I, III, type IV collagen and laminin, fibronectin in IgA nephropathy glomerular capillary loop expression increased significantly, I type III collagen expression in mesangial area also increased significantly, the majority of patients with tubular basement IV also increased the expression of collagen type. And accompanied by large lumpy electron dense deposits.
iga nephropathy is caused by what? These are the biological immune treatment center experts to make the answer for this problem. If your browser process what can not understand the local hospital online experts, experts can consult for your answers carefully.

IgA nephritis should do what?

1 urine test
(1) hematuria: about 40% to 45% of patients in the clinical performance of the naked eye or microscopic hematuria, from 35% to 40% of the patients showed simple microscopic hematuria or microscopic hematuria with a small amount of proteinuria. The sustainable gross hematuria few hours to a few days after to persistent microscopic hematuria, some patients with hematuria disappeared, but often seizures, reproduce gross hematuria attack.
(2) proteinuria: mild proteinuria, general urinary protein excretion <1g/24h, a small number of patients with massive proteinuria or even nephrotic syndrome.
2 immunological tests
(1) IgA increased: from about 1/4 to L / 2 of the patients serum IgA increased mainly multimeric IgA increased.
(2) circulating immune complexes: IgA circulating immune complexes and (or) IgG circulating immune complexes can be detected in the blood of about 1/5 to 2/3 of the children.
(3) anti-"O" elevated titer of anti-"O": A small number of patients.
(4) complement: C3, C4 and more normal.
3 renal biopsy: renal biopsy diagnosis of IgA nephropathy, the renal pathology light mirror change performance for mesangial degree from focal segmental proliferation to diffuse mesangial proliferative ranging. Part mesangial proliferative heavier visible The mesangial insert to form segmental two-track. Sometimes see segmental glomerulosclerosis, capillary collapse, balloon adhesions. Individual lesions severe hyaline change, global sclerosis, individual capillary tube loop necrosis and crescent formation. The Masson staining mesangial area a large number of addicted to the the fuchsin sediment renal immunopathological visible the mesangium significant IgA deposition. Electron microscope for varying degrees of mesangial cells and stromal hyperplasia, electron-dense material by mesangial area, Vice mesangial area extended to the endothelial cells of the capillary wall or on subcutaneous.

The IgA nephritis Western medicine treatment

(A) treatment
Past that the disease is no specific therapy, and relatively good prognosis and treatment measures are not very positive. But in recent years, along with in-depth understanding of the disease, many studies have shown that aggressive treatment can significantly improve the prognosis. IgA nephropathy from pathological changes to the clinical manifestations are very different, very different prognosis, therefore, must be done individualized treatment measures.
A general principle: control the infection, such as repeated episodes of oropharyngeal and upper respiratory tract infection helps reduce gross hematuria, tonsillectomy reduce the onset of gross hematuria remains controversial. Should actively control blood pressure of hypertension in patients with IgA nephropathy urine protein less than 1g/24 hours, target blood pressure control 130/80mmHg following the urine protein than 1g/24 hours, should be the target blood pressure control in 125/75mmHg less.
Adrenal corticosteroids and immunosuppressants onset nephrotic syndrome or rapidly progressive nephritic syndrome in children, and should be of corticosteroids and immunosuppressive therapy. Japan has conducted a nationwide multi-center controlled study, the use of prednisone and immunosuppressive treatment of IgA nephropathy in children, the proportion of its long-term renal insufficiency was significantly lower than the general treatment of children.
Kabayashi had retrospective study of two groups of patients, a group of 29 patients, proteinuria> 2g / d prednisone 1 to 3 years, 2 to 4 years of follow-up, early results show that hormone therapy (Ccr above 70ml/min time) is beneficial for stable kidney function and slow disease progression. Another group of 18 cases of proteinuria ~~ 2g / d of IgA nephropathy corticosteroid therapy, Dipyridamole (dipyridamole) and indomethacin (Indocin) and 42 cases of IgA patients as a control treatment group in stable renal buck and reduce proteinuria aspects, significantly better than the control group.
Lai et al reported a prospective randomized controlled trial, 17 patients daily doses of prednisone 4 months. 38 months compared with 17 cases in the control group, the average observed two groups of endogenous creatinine clearance was no significant difference, prednisone nephrotic syndrome patients with minor lesions, can significantly improve the response rate, but there are some adverse reactions. This research suggests that prednisone IgA nephropathy.
It was reported that a group of adult IgA nephropathy control study to examine the efficacy of azathioprine and prednisone. 66 patients azathioprine and prednisone, the results show that slow down the progress of IgA nephropathy is useful to compare with the control group of 48 patients who did not receive the treatment.
Recently, Nagaoka et al reported a novel immunosuppressant - mizoribine (mizoribine) for the treatment of children with IgA nephropathy, drug safety, easily tolerated, can be long-term use and can significantly reduce the degree of proteinuria and hematuria, repeated kidney in vivo Histological examination confirmed alleviate the severity of kidney tissue.
Cyclosporine reported less, Lai cyclosporine conducted a randomized, single-blind controlled trial, the treatment group and the control group, 12 cases of patients with proteinuria greater than 1.5 g / d, and creatinine clearance The rate of decline Ccr (77 ± 6) ml / min, to cyclosporine 12 weeks of treatment, the plasma concentration level of control at 50 to 100ng/ml. The results show a significant reduction in protein excretion, accompanied by increased plasma creatinine clearance rate, but these changes disappear after the termination of treatment.
In short, the efficacy of immunosuppressive agents in the treatment of IgA nephropathy has yet to be evaluated. The Woo and Wallker observed the effect of combination therapy of cyclophosphamide, warfarin, dipyridamole (dipyridamole) and hormone results compared with the control group, during treatment can reduce proteinuria and stabilize renal function, but the follow-up of 2 to 5 years after renal protection with the control group compared with no significant difference.
Immunoglobulin in an open prospective study, Postoker and others with high dose gamma globulin intravenous, 1 / d, each 2g/kg, qd for 3 months, then changed to 16.5% human serum gamma globulin intramuscular injection, each 0.35ml/kg, every half times, once every six months and found that, after treatment, urinary protein excretion decreased from 5.2g / d to 2.2g / d, hematuria, and white blood cells in urine disappear, the glomerular filtration rate reduced monthly rate by 3.78ml/min slow down to 0.
Fish oil (fish oil) IgA nephropathy patients lack of essential fatty acids, fish oil supplement essential fatty acids, thus preventing early glomerular damage. Fish oil rich in long-chain omega-3-polyunsaturated fatty acids, EPA (Eicosapentaenoic acid), DHA, these substances can be used instead of arachidonic acid, and play a role as a substrate for lipoxygenase and cyclooxygenase, changes in membrane liquidity, reduce platelet aggregation. Collected 20 cases of patients with IgA nephropathy in 1984 Hamazaki done a preliminary study, the treatment group receiving fish oil treatment, renal function remained stable, the control group did not receive fish oil, lower plasma creatinine clearance.
Donadio conducted a multi-center, double-blind, randomized controlled trial in 1994. A total of 55 patients were collected daily oral 12g of fish oil for the treatment group, 51 patients served olive oil for the control group, 68% of the basis of serum creatinine values ​​increased in selected cases, the initial primary endpoint was serum creatinine increase> 50% result is to observe the end of the treatment period (2 years), the fish oil group, only 6% of patients progress, up to 33% in the control group, for 0.03mg/dl annually serum creatinine increased rate in the treatment group, the control group was 0.14mg / dl. The ESRD incidence after four years, the control group was 40%, compared with 10% in the treatment group, the results are statistically significant, no patients discontinued therapy due to adverse events. That fish oil can slow the rate of decline in GFR. In 1999, the author has reported the results of the long-term follow-up of cases, that early and continued use of fish oil can significantly slow down the high-risk patients with IgA nephropathy, renal failure times.
5 Copp recently organized a six-year prospective multi-center double-blind randomized controlled study to investigate the long-term taking shellfish that benazepril, Plymouth [0.2mg / (kg · d)] of moderate proteinuria, renal children and young patients with IgA nephropathy better therapeutic efficacy, and the test is completed in 2004.
In the past been used phenytoin 5mg / (kg · d) treatment of IgA nephropathy found to decrease the level of serum IgA and polymeric IgA, and hematuria decrease in the number of attacks, but not reduce circulating immune complexes, and the long-term effect is not certainly, in recent years, has been rarely used.
Chinese medicine treatment of IgA nephropathy also have a certain effect, moderate proteinuria, use Tripterygium the lmg / (kg · d) treatment for 3 months, will receive significant effects.
6. Dialysis and renal transplantation feasible dialysis and transplantation in the treatment of patients with end-stage renal failure.
(B) The prognosis
Adult IgA nephropathy after 10 years, about 15% progress to the terminal renal failure, increased to 25% to 30% after 20 years. The prognosis of IgA nephropathy in children better than adults, Yoshikawa reported that after 20 years, 10% progressed to terminal renal failure. Many prognostic factors, severe proteinuria, hypertension, severe glomerulosclerosis and interstitial tubule lesions are indicators of poor prognosis; men also easy to progress; the gross hematuria prognosis still controversial. According to reports, IgA nephropathy patients from renal normal since annual GFR reduction rate of 1 ~ 3ml/min the performance nephrotic syndrome patients with IgA nephropathy GFR decreasing rate 9ml/min. With hypertension, GFR reduce speed to up to a year 12ml/min Therefore, control of blood pressure and proteinuria is essential in the treatment of IgA nephropathy.

Therapeutic treatment of different types of IgA nephropathy

In the theory of Chinese medicine, not only medical treatment with drugs, you can also rely on diet to ease the symptoms. Today to introduce the therapeutic treatment of different types of IgA nephropathy details see below:
, Spleen and kidney yin chronic IgA nephropathy PERSISTING
Symptoms: visible microscopic hematuria with proteinuria, fatigue, weakness, waist and knee pain, cold or dysphoria heat, spontaneous sweating or night sweats, thirst or throat pain, pink tongue with scalloped edges or fat tongue thin white or thin yellow and dry, rapid pulse and weakness.
Diet: should the double kidney Yin Spleen, hemostatic rule is, heterophylla, Astragalus, habitat, yam, Alisma the 15g, the thistle 30g, Poria 20g, cornus, paeonol the 10g, notoginseng powder 1g , rice 100g, sugar amount. The first nine flavor cook the juice into the rice congee join notoginseng powder, sugar and absorbed, can be boiled again.
(2), liver-kidney chronic IgA nephropathy PERSISTING
Symptoms: visible and pain associated with microscopic hematuria or proteinuria, five upset hot, dry throat, leader of dizziness, tinnitus, low back pain, dry stool, red tongue Taigan rapid pulse string breakdown.
Diet: should be used to nourish the liver and kidney, bleeding and other rule is, Poria, thistle, 30g, habitat, yams, Silver Flower 20g, Rhizoma Imperatae, Alisma 15g, Anemarrhena, Cork 12g, cornus fried Gardenia child each 10g, blood glutinous rice 100g, honey to taste. 11 taste cook the juice into the blood glutinous rice congee, seasoning and honey. 1 day, 2 doses.
, Firelight the flaming type acute exacerbation period IgA nephropathy
Symptoms: mind Fanre, mouth sores, urine the redness or microscopic hematuria, red tongue, thin yellow coating, rapid pulse.
Diet: should adopt the pure heart Chufan, cooling blood to stop bleeding and other rule is, thistle 30g, habitat 20g, the Rhizoma Imperatae 15g, bamboo leaves 12g fried gardenia Health hay 10g, rice 100g sugar amount. The first six flavor cook the juice into the thin rice boiled thick porridge, can add sugar to taste. 1 day, 2 doses.
Bladder damp-heat in acute exacerbation of IgA nephropathy
Symptoms: visible urinary frequency, urgency, urinary fever, urinary astringent, painful urination, low back pain, dry stool, urine redness or microscopic hematuria, red tongue, yellow coating, rapid pulse.
Diet: should adopt clearing heat, cooling blood to stop bleeding and other rule is the thistle, talc (cloth) 30g, habitat 20g, fried Puhuang, Oujie charcoal, fried Gardenia 10g, bamboo leaves 12g, angelica, licorice of 6g, through the grass 3g, red bean, rice 60g, sugar amount. Top 10 flavor cook the juice into the red bean, rice congee can add sugar to taste. 1 day, 2 doses.

Common symptom of IgA nephropathy

Learn the common symptoms of IgA nephropathy has great significance for the timely detection and treatment of IgA nephropathy. The general symptoms of IgA nephropathy is relatively diverse, but can generally be divided into asymptomatic with two obvious symptoms.
Common symptom of IgA nephropathy, we have the following from both analysis, respectively.
A patient is often asymptomatic urinary abnormalities, only found in the examination of microscopic hematuria and mild proteinuria, occasional tube. The small number of patients may manifest as nephrotic syndrome, severe hypertension and chronic renal failure. This makes the increased occult disease, is not easy to detect, which often lead to IgA nephropathy incidence of occult exacerbations, is not conducive to late treatment.
Another common in patients with obvious symptoms. As a result of respiratory infections or gastrointestinal tract, urinary tract infection 1-2 days gross hematuria last a few hours or a few days later to become microscopic hematuria after varying degrees of proteinuria or microscopic hematuria. A small number of patients may have a transient high blood pressure and increased blood urea nitrogen, and individual patients or even acute oliguric renal failure syndrome, but can ease after symptomatic treatment and rest.Gross hematuria disappeared, about 60% of patients will relapse after respiratory tract infection, hematuria again.

Clinical diagnosis and identification of IgA nephropathy?

How clinical diagnosis and identification of IgA nephropathy? IgA nephropathy is a unique glomerular nephropathy, IgA nephropathy, other nephropathy, confirmed IgA nephropathy must have a pathological examination of renal biopsy immune.
Of course, at the time of diagnosis is more common diagnosis, such as young men or microscopic hematuria and (or) asymptomatic proteinuria in patients with occurrence of pharyngitis synchronization hematuria, should be considered from the clinical IgA nephropathy may however still You must do the renal biopsy diagnosis.
How clinical diagnosis and identification of IgA nephropathy? IgA nephropathy diagnosis is often confused with some other kidney, then they need to IgA nephropathy and some other kidney differentiated. Mainly to identify with the following diseases:
Allergic purpura nephritis: Patients may present with microscopic hematuria or gross hematuria. Renal biopsy may have the same broad primary IgA nephropathy the mesangial area IgA deposition. However, the HSPN patients often typical skin purpura, abdominal pain, joint pain performance.
Thin basement membrane nephropathy: thin basement membrane nephropathy main clinical manifestations of recurrent hematuria, urine Pf4 level can help with IgA nephropathy identify. Must depend on renal biopsy electron microscopy to check the with IgA nephropathy identification.
3. Streptococcal infection acute glomerulonephritis: IgA nephropathy is also likely to occur in young males in upper respiratory tract infections (acute tonsillitis) hematuria may have proteinuria, edema and hypertension, or renal damage .
4 non - IgA mesangial proliferative glomerulonephritis: non-IgA mesangial proliferative glomerulonephritis with IgA nephropathy is difficult in clinical identification. To rely on the renal biopsy immune pathological examination to identify.

Concern about iga nephropathy prognosis factors

IgA nephropathy is the most common primary glomerulonephritis, but its pathogenesis is not clear, the general prognosis. According to statistics, there are about 3 percent iga nephropathy patients eventual development of the disease to end-stage renal disease. Factors also concern about iga nephropathy prognosis is particularly necessary.
Iga nephropathy treatment with the treatment of the continuous advancement of technology has also been considerable development. The new study suggests that further treatment will be aimed at preventing the inflammatory damage caused by mesangial IgA deposition and reduce by the infiltration of neutrophils and their release cytokines delay kidney deterioration. Iga nephropathy prognosis of some of the factors associated with concern about iga nephropathy prognosis factors, these factors iga nephropathy prognosis more.
Concern about iga nephropathy prognosis factors, and prognostic factors:
Persistent microscopic hematuria associated with proteinuria, the prognosis is poor.
2.IgA nephropathy in patients with hypertension, especially difficult to control severe haypertension and poor prognosis.
3. Pregnancy patients with IgA nephropathy, IgA nephropathy in patients with hypertension and renal dysfunction, pregnancy is generally safe.
4 male patients, the greater age of onset and poor prognosis.
5.IgA nephropathy showed patients with nephrotic syndrome, if mild renal pathological changes, the the good reaction glucocorticoid treatment, the prognosis is good.
6, severe proteinuria often prompted the eventual development of renal insufficiency, the prognosis is poor.

Expert online: the IGA nephropathy, renal biopsy report, the severity?

To do in Shanghai Xinhua Hospital renal biopsy results are as follows:
Pathological diagnosis:
IGA, C3
13 only glomerular
Most of the glomerular mesangial cell ball, or segmental mild hyperplasia with matrix increase
Tubular multifocal necrosis, atrophy, and see part of the luminal cells and protein in tubular form,
Renal interstitial show more inflammatory cell infiltration
Renal blood vessels showed no abnormal
IGAN (mesangial proliferative type)
Do not know that this is lee's a few levels, how to see if there is no crescent formation?
Doctor to have:
6 day prednisone (Shanghai Xinyi out) 30mg
Caltrate 1 a day
There is a what enteric-coated tablets (stomach) and a raised bone specific forget.
Had the disease very hard to accept and originally feisty admit defeat, a lot of things can not do, can not be too tired, and the future receive the impact, only 27 years old, newly married, not kids. . .
Pain!
Experts answer
Telephone communication, if you want to get a more detailed treatment programs, treatment, care problems to the online experts to submit a more detailed condition or fax your case a single further consultation.

Expert Online: Children's immune function in IgA lower than normal, calcium

9-year-old boy, because every month a cold cough to go to the hospital for immune function testing and detection of trace elements, results showed that the humoral immune IgA below the normal value of 0.91g / L (normal range is 1.27-1.93g / L) detection of trace elements of calcium lower than normal. this case do not need to take to enhance the immune drugs, In addition, the calcium supplement or vitamin D. hope to hear the doctor's advice, thank you!
Experts answer
One can take it. This will enhance the child's immune system. But this is only a temporary solution. (2) calcium and vitamin d supplement. The best outdoor activities every day two hours. (3) recommend nutritional supplements. Milk, beans, lean meat, liver, etc., can eat more. Children more exercise, exercise, exercise habit.
Expert online: the IGA four hardening, can be pregnant?
17 glomeruli, four small balls sex sclerosis, 3 balls segmental sclerosis with adhesions, a small ball large fibrous crescent formation with segmental sclerosis, three small ball balloon adhesion the rest of the glomerular lesions, diffuse mild to moderate proliferation of mesangial cells, moderate increase in mesangial matrix. Found that blood pressure 140/100, may I ask, if negative, but also be pregnant?
Experts answer
Ah, I just obtained the marriage certificate when took a snapshot to pay more than you, the fee for only 9 dollars, I pay 66, gave the four photos, nothing have. According to a photo took me 57 quick Boyd, Civil Affairs Bureau, is a liar? So, now is not to say, the next time you go to go, even if the liar 40 dollars took a set of passport but also the value, after looking for work can be used, medical examinations, although the price of 50 dollars is , but I think the transceiver is not correct, general interviews are finished talent of being admitted will pay medical examinations of By the time you look at the interview were many people in terms of it, I wish you good luck.
Expert Online: iga nephropathy.
I June renal biopsy to detect iga nephropathy 3. Segmental glomerular sclerosis. Inpatient treatment for more than a month.
Discharged after hormone, and traditional Chinese medicine with western medicine treatment. Prednisone 10.
Every month to check the improvement in urinary protein June acute exacerbation after admission, no. Was always no.
Occult blood was discharged after two plus eat more than two months of traditional Chinese medicine, a month less a plus.
No occult blood, protein-free.
Usually also normal. Hormone every half months less one, nor how to gain weight. Weight did not change.
Asked how prognosis, how long will relapse? I this case also need the Yange She salt it?
The face to grow up point, and this hormone subtraction How often do you think the same as before.
Do not copy the answer Thank you
Experts answer
Prognosis is good, good control of their diet, especially salt intake control, too much salt will increase the burden on the kidney. Face grown up with the use of prednisone withdrawal after recovery.

Expert online: VCA-IgA (EB virus antibody) was sexual

I am a friend of one of the test results! The expertise to answer!
VCA-IgA (EB virus antibody) positive
APTT H
MO monocyte percentage of H
HCT hematocrit L
MCHC (RBC mean corpuscular hemoglobin concentration) L
MPV (mean platelet volume) L
Please do not understand do not pretend to understand,
Relationship to human life, and the expertise to answer!
12,000 points thanks ~ ~ ~ ~
My friend is the man! Father died due to nasopharyngeal ~ ~
Experts answer
EB virus (Epstein-Barrvirus, EBV) belongs to the subfamily of Herpesviridae R DNA virus. Widely exist in the world, become a lifelong latent infection in human infection, under certain conditions, activation, and can be transformed into lymphocytes. Earlier phase of infection in developing countries, about 3 to 5 years of age has reached its peak population infection rate, about 50% of infected; later in the developed world, to its peak at about 15 to 20 years old. Now known pathology of EBV and the following four different diseases: infectious mononucleosis syndrome (IM), Burkitt's lymphoma (Burkitt lymphoma), nasopharyngeal carcinoma and immunocompromised individuals polyclonalB-cell lymphoma. Different parts of the research shows that women of childbearing age is basically this end virus serology. EBV can infect the fetus and cause congenital damage, the problem will be very serious. Whether by the intrauterine birth canal or breast milk spread on the virus and cause congenital infection, there has been controversy. Related to nasopharyngeal carcinoma. Answer to supplement it may be related to nasopharyngeal carcinoma. Genetic. . . . The answer to add the best to the hospital confirmed that this is not good to say
Telephone communication has been, if you want to get a more detailed treatment program or treatment, nursing problems, to submit a more detailed condition or fax your case a single to the online experts for further consultation.

iga nephropathy not Western medicine how treatment?

iga nephropathy not Western medicine to how it treated? We know that kidney disease is an autoimmune disease, this is because the immune system abnormalities. In this case, a large number of antibodies and antibody immune complexes, as well as other related sedimentation in the kidneys, causing inflammation of kidney tissue directly. Although the main factors of the inflammatory response of renal damage, but the deposition of immunoglobulin and antibody immune complexes the root cause. Deposition in the kidneys, inflammation and kidney damage. Therefore, the basic approach is to remove deposited to stop kidney disease.
iga nephropathy Western medicine do not how it treated? nephropathy immune to extend the patient's life by stopping kidney disease. Immunotherapy, traditional Chinese medicine is used to adjust the patient's immune system. We know that a healthy person, he is free from various diseases, it is because he has a strong immune system that helps eliminate bacteria and viruses. When the system is weak or not normal, he began to be different diseases. When the antibody immune complex formation and deposition in the kidneys, inflammation, and therefore the formation of kidney disease. Immunotherapy treatment for kidney disease is only by strengthening the patient's immune system, as well as improve their self-curative capacity.
Treatment of immune treatment of nephrotic principles to eliminate the cause of kidney damage. Kidney disease is an autoimmune disease, it occurs because a large number of immune complexes (antibody immune complex deposition in the mesangial area), part of the kidneys, and cause inflammatory and immune responses. The antibody is the number of immunoglobulin, ranked second only to the antibody.
Immunoglobulin deposition in the mesangial area, the inflammatory and immune responses to get rid of these foreign substances. However, when our strong immune system, help us to remove these harmful substances, our own renal tissue destruction as well. In addition, based on clinical investigations, damage the kidneys caused by inflammatory and immune responses than the more serious immune complexes.
A. Make it clear that the number of immune complex deposition in glomerular mesangial area.
Two. Clear circulating immunoglobulin A immune complexes from the blood to prevent immune complex deposition in glomerular mesangial area.
3. Stop the inflammation, and prevent further kidney damage.
4. Adjust the patient's immune system to clear immune complex deposition in the mesangial area.
5 Protection of the patient's immune system, to avoid the recurrence of kidney disease.
Experts: chronic iga nephritis can be cured of Chinese medicine or Western medicine
Chronic nephritis can cure okay Chinese medicine or Western medicine? In the field of modern Chinese medicine for the treatment of IgA nephropathy is "strengthening the economy" treatment! Modern medicine, yin deficiency heat is the main pathogenesis of IgA nephropathy, damp, evil drug, blood stasis The blood is induced by IgA nephropathy and aggravating factors.
Kidney by the rich capillary lesions prone to blood damage, blood runs sluggish Erzhi blood stasis. IgA nephropathy at the beginning from the onset to the kidney for the lesion center, a long time in human blood will run the abnormal formation of blood stasis. IgA nephropathy pathology of mesangial immune complex deposition, increased mesangial cells, mesangial matrix increase, balloon adhesion, occlusion of capillary loops, glomerular sclerosis, tubular atrophy and interstitial fibrosis are kidney local blood stasis.
Can be cured of chronic nephritis Chinese medicine or Western? Hot and humid poison evil IgA nephropathy induced by external factors, but also a pathological product of IgA nephropathy. Hot and humid poison the evil and the disease activity of IgA nephropathy is an important factor for more severe disease. Hot and humid the basis of the pathological immune response, damp, may be signs of cytokines and inflammatory mediators active in the origin of the disease stage, immune complexes continuously deposited in the kidney, direct damage to the glomerulus.
IgA nephropathy in Chinese medicine theory, the experts should focus on treatment of IgA nephropathy around the virtual, the ebb and flow of blood stasis, heat, moisture change, stasis disinfection, repair, mesangial cells, reducing the kidney burden, prevention and treatment of healthy kidney cells to be replaced must also be repaired, new life, to achieve new
Experts answer
Iga nephritis chronic can be cured Chinese medicine or Western medicine? In the field of modern Chinese medicine for the treatment of IgA nephropathy is the treatment of "strengthening the foundation of modern medicine, yin deficiency heat IgA nephropathy
Telephone communication has been, if you want to get a more detailed treatment program or treatment, nursing problems, to submit a more detailed condition or fax your case a single to the online experts for further consultation.

New method:immunotherapy to treatment iga nephropathy

IgA nephropathy is a common cause of glomerulonephritis. Although it is a benign disease in most patients, chronic renal failure and ESRD occur in about 20-40% of patients within 20 years of presentation. Currently, no cure exists for IgA nephropathy, but therapies that can delay the onset of need for dialysis and transplantation are available.
New method:immunotherapy to treatment iga nephropathy
Then what are Immunotherapy ?
Immunotherapy is an advanced medical treatment created on the basis of Chinese herbal treatment. In clinical, Immunotherapy is divided into six steps and each of them focuses on different purpose.
How does Immunotherapy treat IgA Nephropathy?
IgA Nephropathy is an autoimmune disease and it occurs because large amounts of IgA immune complexes deposit in mesangial area and cause kidney damages. Therefore, the key point of treating IgA Nephropathy is to clear immune complexes away from the kidneys.
Immunotherapy is a medical treatment which achieves the purpose of clearing immune complexes away through adjusting immune system as well as strengthening self-curative ability.
In clinical, Immunotherapy is divided into several steps and each of them focus on different purpose. We know clearing immune complexes is the best and only way to stop IgA Nephropathy, but in Immunotherapy, removing immune complexes circulating in the blood in advance is very important as it can prevent more immune complexes from deposing in mesangial area. When blood is purified, Chinese herbs will be used to adjust IgA Nephropathy patient's immune system and increasing immunity. We know IgA immune complexes do not belong to our kidneys, so as our immune system becomes more and more powerful, they will be cleared away little by little.
No IgA immune complexes in mesangial area, no further kidney damages and consequently, IgA Nephropathy is brought under control.

IgA nephropathy daily daily

For patients with IgA nephropathy, we advocate low lipoprotein eating, to limit the excessive intake of dietary protein in the food phosphorus; often accompanied by pharyngitis and tonsillitis due to IgA nephropathy, TCM is mostly Yin deficiency, it is to remind patients with IgA nephropathy in the diet should light, the ban spicy thick tired of the goods, and avoid alcohol.
About 10 IgA patients with favorable side, available to patients and their families Reference:
1 loofah Yin: a segment of old loofah, loofah wash boil water, cooling blood to stop bleeding effect. Applies heat Shang Yin network cause of hematuria patients with IgA nephropathy.
Chine Bamboo Shu water: Rhizoma Imperatae fresh 250g, Jianshui, can put the brown sugar, IgA nephropathy patients may use this when the beverage drink.
The 3 Chine porridge: fresh Rhizoma Imperatae 60g, plus adequate water, and cook for half an hour later, take the Chine water porridge, a times a day.
Smilax glabra turtle soup: a turtle, 90g of Smilax glabra, the turtle put in hot water, making urination, then killed, cut wash, take offal, Smilax glabra, the amount of water and cooking, can be a little salt seasoning.
Carp and winter melon soup: carp 1, about 250g, to the phosphorus and offal, melon around 500g, cook, come a little seasoning salt, fish soup.
6. Caterpillar fungus bird chicken soup: Cordyceps 10g, a black chicken, 10 quail eggs, t eat 1-2 times a week. This side Yiqibushen vital essence the Jiufu physical fitness, increase resistance to disease, reducing the chance of infection, reduce the symptoms of IgA nephropathy and hematuria onset of the times.
Shepherd's purse porridge: a new shepherd's purse 250g, washed, chopped, with m 100g porridge consumption, governance hematuria patients with IgA nephropathy.
. Black Douyu: black beans, Coix seed, chain. Jujube meat 50g, m 200g, plus adequate water, porridge eating, can cure high-protein, hypoalbuminemia patients with IgA nephropathy.
Gorgon kidney soup: the Gorgon 50g, when residual 30g, a pig kidneys, cut open salt and liquor scrub, to taste, and kidney soup, low salt food, one day, cure proteinuria more of patients with IgA nephropathy.
10 Gorgon meal porridge: Gorgon flour 30g walnut meat 15g red dates 10 to the core. Gorgon powder first with cold water into a paste into the boiling water stirring, join the walnut meat, jujube meat gruel paste, daily consumption. Bushengubiao effect of governance kidney of proteinuria, hematuria.
Patients with IgA nephropathy is suitable for the diet to restore side, need to go through the guidance of professional doctors.

How to determine the IgA nephropathy

IgA nephropathy early and not have any symptoms, it is likely before the onset of the patient's body, dormant for many years, even decades. The first symptoms of IgA nephropathy may be hematuria, in patients with a small cold, sore throat or other infection may lead to hematuria. Hematuria is divided into two kinds, gross hematuria and microscopic hematuria. Gross hematuria the urine contains large amounts of blood cells was pink or brown or even cola color. Microscopic hematuria only by virtue of special detection can be detected. While hematuria is not specific symptoms of IgA nephropathy, and excessive exercise can lead to hematuria. So how do we determine the IgA nephropathy?
First, the doctor or nurse through urine testing to determine the existence of blood cells or proteins in the urine of patients. Method with specific chemicals to the test strip into the urine samples, if the test strip color represents the urine contains red blood cells or proteins. Red blood cells in urine together to form a tube, urine tube, the patients with kidney filtration function may have been damaged.
Followed by a blood test to detect the blood of patients with metabolic waste level, the two most important indicators for creatinine and urea nitrogen. The main duties of the kidneys from the body of metabolic waste, so that blood creatinine and blood urea nitrogen level was increased, decreased kidney function. Under normal circumstances, the greater the likelihood of patients developed renal failure diagnosed when creatinine is elevated.
Determine renal function in patients after the doctor may recommend a kidney biopsy to determine if patients with whether people with IgA nephropathy. Renal biopsy refers to the use of special equipment to take a small piece of kidney tissue of patients observed in patients with renal deposition of immune complexes through a microscope to determine the extent of the damage of the kidneys, so as to formulate the best treatment program. After diagnosis of IgA patients require regular blood tests to monitor kidney function.

How to diagnosis of IgA nephropathy

In the country of Japan, the law school-age children must receive routine urine examination. Therefore, children are often in the early IgA nephropathy will be checked out. In China only in the urine into the cola color or brown, people will note that the kidney problem.
There are many reasons that cause hematuria symptoms. Because many doctors are unfamiliar with IgA nephropathy, the patient may go through a series of urinary tests to determine if there is urinary tract infections or congenital malformations. But as long as the red blood cells in the urine under a microscope, you will find these red blood cells is no longer full and mellow, they look ragged edges, what seems to have been bitten by the same. This glomerulus has been damaged, but not yet confirmed what type of glomerulonephritis.
A doctor first thought may be glomerulonephritis caused by streptococcal infection, such symptoms of nephritis and IgA nephropathy, but with IgA nephropathy will heal this nephritis is usually the case. To rule out the possibility of post-streptococcal glomerulonephritis, patients need a variety of tests, including complete blood count and blood urea nitrogen, creatinine, Determination of anti-streptolysin blood.
Your doctor may also ask you to creatinine clearance test. Detected in the blood creatinine levels on the basis of the analysis in the urine of 24 hours to assess the level of kidney function, in order to determine the glomerular filtration rate. Creatinine is the end product of muscle metabolism, one of the most important functions in the kidney is cleared of creatinine in the blood. Creatinine clearance test does not help the doctor determine exactly what type of glomerulonephritis, but can determine the severity of inflammation and kidney damage. Kidney approximately every minute filtered five ounces of blood, IgA nephropathy in patients with glomerular filtration rate is decreased, which lead to glomerular capillary filtration area is reduced due to the inflammatory response, leading to the glomerular filtration rate reduced.
Proteinuria and hematuria, or other kidney disease, lack of features, such as azotemia or significant edema may be caused by IgA nephropathy, but only to the final diagnosis of renal biopsy.

Patients with IgA nephropathy of dietary advice

The survey shows that in the case of normal renal function, IgA nephropathy patients do not need to deliberately restricted diet. But low salt, low protein, high-quality daily diet is still necessary. When patients with renal insufficiency, the need to reduce intake of salt, protein and water. The following is the need to pay attention to some of the patients with IgA nephropathy in the diet.
Control the intake of salt and water
Severe edema, high blood pressure and urinary symptoms, patients should eat salt-free diet; daily intake of water is maintained at between 800-1500 ml; can not eat pickles, pickles, soy sauce, pickled, salted, fermented bean curd and mustard a class of sodium-rich food. If the patients with edema subsided, blood pressure, urine output increased, may be an appropriate intake of salt intake to 2-3 grams.
Control of protein intake
Excessive intake of protein can cause the metabolism to produce more nitrogen and increase the burden on the kidneys. Urine as little cause the body's metabolic waste can not be excreted to accumulate in the human body, causing a series of symptoms of poisoning. Therefore, patients should Eat less meat, eggs, soy and other protein-rich food. To be the patient's condition improves before a moderate increase protein intake.
Consumption of foods rich in vitamins
Fresh fruits and vegetables and other alkaline foods can provide many essential vitamins and promote the recovery of renal function.
More fresh light taste and diuretic effect of food
If the decline in renal function in patients with renal insufficiency, their daily diet depends on the condition of the patient. Although a lot for IgA patients, dietary restrictions, but if patients and their families in the diet more effort, you can effectively reduce the recurrence rate of IgA nephropathy, and help patients return to normal life trajectory as soon as possible .

Non-specific symptoms and signs of IgA nephropathy

The study found that, IgA nephropathy and there is no specific symptoms or signs. So how to determine whether risk of IgA nephropathy?
IgA nephropathy is the most prominent clinical manifestations of recurrent gross hematuria, usually accompanied by proteinuria, but not necessarily. Sustained asymptomatic hematuria without proteinuria symptoms we call the isolated hematuria. Only a small number of patients with isolated hematuria symptoms. With many patients with glomerular nephropathy urine red blood cells, red blood cells in the urine of IgA nephropathy patients for the heterogeneity of red blood cells (compared with the normal red blood cell size and shape have change).
Often accompanied by symptoms of low-grade fever and low back pain due to repeated episodes of hematuria, this situation will often be misdiagnosed as a urinary tract infection or urinary stones. Using a microscope to carefully observe the Urine red blood cells, red blood cells showing non-uniformity of the glomerular lesions, strong glomerular lesions caused by the root cause of the hematuria symptoms.
However, the same symptoms may also occur in thin basement membrane nephropathy, hereditary nephritis and proliferative glomerulonephritis. By renal biopsy, immunofluorescence or electron microscopy easily separated with IgA nephropathy. In addition, proliferative glomerulonephritis also the symptoms of serum complement levels. The X chromosome inherited kidney disease, including hereditary nephritis (excluding from father to son type) deafness symptoms usually appear. By renal biopsy and electron microscopy of thin basement membrane nephropathy and IgA nephropathy easily separate areas.

The symptoms of IgA nephropathy

IgA nephropathy can occur at any age, although relatively rare, but children may also be suffering from IgA nephropathy. Early IgA nephropathy did not show any symptoms, but its diagnosis or evidence-based. Many children with presenting symptoms similar to adult patients. If the disease early can make a clear diagnosis, help to prevent the occurrence of future complications.
Hematuria
Hematuria means blood in urine. May be microscopic hematuria may be gross hematuria. The study said the hematuria is usually accompanied by cough, respiratory infection or fever. As urine contains red blood cells so the colors are deeper than normal urine. Hematuria, and will not be in the active phase of IgA nephropathy continues to appear, or only appear in the active phase of the disease.
Proteinuria
Proteinuria with a lot of protein in the urine. IgA nephropathy-related research institutions, proteinuria and hematuria at the same time is the most common symptoms of IgA nephropathy. Part of the impaired kidney function and lead to the appearance of proteinuria. Under normal circumstances, the kidneys filter out the protein from the urine and then re-absorption, but due to IgA caused damage to the kidneys, resulting in the impairment of this function does not filter out the protein in the urine. The existence of protein in the urine, the patient will appear foamy urine. The urine test can detect the content of protein in the urine, if the protein content of more than 150 mg per day, then proteinuria is more serious.
Fatigue
Reported that fatigue is the most common symptom of IgA nephropathy. This extreme sense of fatigue is usually accompanied by sore throat, headache or low-grade fever.Due to extreme fatigue, the patient is not even doing homework energy are not. And often accompanied by hematuria and proteinuria.
Abdominal pain
IgA nephropathy in children usually experience appendicitis-like abdominal pain of torture. The pain usually occurs in the abdomen, middle or right lower quadrant. Although not yet determined the cause of the abdominal pain, accompanied by abdominal pain, symptoms of hematuria and proteinuria can also be used as one of the basis for the diagnosis of IgA nephropathy.
Side abdominal pain
Back or side abdominal pain associated with IgA nephropathy. This pain of varying severity, ranging from mild back pain to unbearable pain of gun, this will cause the patient can not walk properly. Symptoms in pediatric patients who are rare.
Itching
Itching or itching is common in children with IgA nephropathy. Children accompanied by itching urticaria. The occurrence of such symptoms and the deposition of IgA in children with skin.
Chronic renal failure
Chronic renal failure symptoms include edema (extremities and throughout the body edema), high blood pressure, fatigue, headaches, cramps and insomnia. These symptoms in pediatric patients who are relatively rare, only 5% to 10% of IgA in children with the disease will develop chronic renal failure.

Etiology and complications of IgA nephropathy

The nephropathy pairs of lentils organ size of a fist, located on both sides of the back spine. Each kidney through the filter flows through the kidney's blood from the capillaries (glomerulus) in the waste and excess water to play a role. Blood filtered again to start a new round of blood circulation. Filter out waste as urine into the bladder and then excreted.
IgA is an immunoglobulin class of antibodies, and assume responsibility for the eradication of the antigen plays a key role in the immune system. However, it is due to the deposition of this immunoglobulin in the glomeruli, which leads to impaired kidney filtration function, which immediately caused IgA nephropathy.
After years of research, but the reasons leading to IgA deposition is still a mystery.
May result in the etiology of IgA nephropathy include:
Genetic
Certain family of multiple IgA nephropathy, and to the occurrence of IgA nephropathy and genetic relationship.
Cirrhosis of the liver
The healthy kidney tissue lesions occur in one of the scar tissue is IgA nephropathy as a causal factor
Celiac disease
Digestive diseases caused due to consumption of commonly found in the gluten proteins in grain may trigger IgA nephropathy
Dermatitis herpetiformis
A gluten intolerance accompanied by itching, blisters and symptoms of skin diseases
Infection
HIV infection and various types of viral infections
IgA nephropathy in the course of the disease varied, but also vary from person to person. Although some patients many years of illness, but stable condition, basically no complications. In fact, many times some of the symptoms is not likely to be diagnosed. In addition some patients may occur an even more complications.
Hypertension
Kidney damage caused by IgA deposition can cause elevated blood pressure. This can lead to further damage of the kidney.
Acute renal failure
Once the kidney deposition of IgA in the loss of filtration function, metabolic waste generated will be much more rapid deposition in the blood. At this point, the patient will have to dialysis treatment. After dialysis, the patient's body wastes, toxins will be excreted through the machine, which originally is the responsibility of the kidneys. Dialysis, the doctor will needle through a special access point into your arm, after the blood through the catheter into the dialysis machine. Filtered clean blood to flow back to your body will go through the other end of the catheter.
Chronic renal failure
IgA nephropathy can cause the kidneys gradually lose function. Once renal function is completely lost, and patients in order to survive only accept permanent dialysis or a kidney transplant.
Nephrotic syndrome
Nephrotic syndrome is a series of symptoms of kidney disease caused by glomerular damage. Including high proteinuria, hypoproteinemia, eyelids, feet and abdominal edema.

Have to do with IgA nephropathy renal biopsy?

IgA nephropathy must do renal biopsy? IgA nephropathy is a kidney inherent features of immunoglobulin A deposition mainly caused by cell damage syndrome. Puncture needle into the kidney of the body, remove the small amount of kidney tissue for pathological analysis. There are two kinds of ways, First, the open puncture of the kidney biopsy method, first through the skin puncture renal biopsy in France, now mainly used the latter approach, many clinical genotyping method can not confirm the diagnosis, prognosis, etc., there are many using renal biopsy is useful in diagnosis, guide treatment, prognosis, and to investigate the clinical classification and pathological type of relationship, but also raise an important means of kidney disease clinical and research level. For in-depth study of the field and to explore the pathogenesis of kidney disease, and promote clinical and scientific research of kidney disease in depth, the development of kidney disease, has an important role.
Renal biopsy notes you know? Renal biopsy preoperative preparation? Someone to do before the renal biopsy was very worried, do not know whether they can adapt the renal biopsy, renal biopsy in the preoperative preparation should be noted that what impatience receive a kidney puncture, this practice is very strict taboo. Here's some Notes on renal biopsy.
Renal biopsy is an invasive examination, and choice of puncture cases not only need to master the adaptation levy, they also had to rule out contraindications.
⑴ absolute contraindications: ① significant bleeding tendency, ② severe hypertension, ③ mental illness or do not match operator, ④ solitary kidney, ⑤ small kidney.
⑵ relative contraindications: ① active pyelonephritis, renal tuberculosis, hydronephrosis, or empyema, renal abscess or renal abscess. ② renal tumor or renal artery aneurysm. ③ polycystic kidney disease or kidney large cysts. (4) kidney position is too high (deep breathing, kidney and the lower pole up to 12 ribs) or wandering kidney. The ⑤ chronic renal failure. The ⑥ obesity. ⑦ severe ascites. ⑧ heart failure, severe anemia, low blood volume, pregnant or elderly persons.
Before the renal puncture is well prepared is an important part in reducing complications. Preoperative should undertake the following tasks:
The ⑴ explain the necessity and safety of renal biopsy and possible complications to the patients and their families, and with the consent of the patients and their families agree. Explained to the patients with renal biopsy operation, the lifting of the patient's fear, in order to obtain the cooperation of the patient. Allowed to practice breath holding (renal biopsy will be temporarily hold your breath) and urinating in bed (bed 24 hours after renal biopsy) for close coordination.
⑵ tested positive, clotting time, platelet count and prothrombin time in order to understand whether the bleeding tendency.
⑶ check creatinine clearance, serum creatinine and blood urea nitrogen of kidney function, check the isotope renogram understanding of the sub-renal, and make a B super understanding of kidney size, location and activity.
(4) check the blood type, prepared blood, the skin of the preoperative routine cleaning kidney area.
⑸ surgery 2 to 3 days before the oral or intramuscular vitamin K
⑹ acute renal failure in patients with renal biopsy In addition to the laboratory prothrombin time, but also determination of the kaolin partial thromboplastin time, In addition to the check platelet count, should from time to time to check platelet function (aggregation, adhesion and release function), if abnormal, should be corrected before surgery. Abnormal platelet number and function can puncture the day before surgery, infusion of fresh platelets. Bleeding time cold precipitate correction of infusion rich clotting factor. Severe renal failure patients the best in the renal biopsy before the hemodialysis several times, 24 hours before the renal biopsy to stop dialysis, when the end of dialysis to protamine and heparin, and review of the clotting time of the test tube method, before the renal biopsy to confirm that the heparin The effect disappeared.
⑺ surgery the front of the empty bladder. Renal biopsy is usually divided into three categories: the the ⑴ through the skin puncture renal biopsy technique, the present study has been widely recognized and applied renal biopsy; ⑵ surgery to look directly into the open renal biopsy; ⑶ renal vein puncture renal biopsy surgery.
To sum up, the clinical significance of renal biopsy the following main points:
⑴ clear diagnosis: renal biopsy can make more than a third of patients with clinical diagnosis to be corrected.
(2) to guide treatment: nearly a third of patients with clinical treatment programs to be modified by renal biopsy.
⑶ prognosis: renal biopsy can more accurately evaluate the prognosis of patients with kidney disease.
In addition, sometimes in order to understand the effects of treatment or to understand the pathological progress (such as crescentic glomerulonephritis, lupus nephritis and IgA nephropathy, etc.) also need to be repeated kidney pathology.
Have to do with IgA nephropathy renal biopsy?
Different period of development of kidney disease pathological changes inconsistent. Same IgA nephropathy, pathological performance for almost all stages of development from a near-normal renal tissue to the majority of glomerular sclerosis. Therefore, to understand the morphological changes in kidney tissue clinicians to determine the condition, treatment of disease and prognosis and provides an important basis. It can be said that the kidney pathological examination of the development of nephrology in the development of a leap. At present, kidney pathology results has become the gold standard for diagnosis of kidney disease.

What are the main symptoms of IgA nephropathy?

The most common symptom of IgA nephropathy proteinuria and hematuria. Hematuria is divided into microscopic hematuria and gross hematuria, microscopic hematuria refers to the red blood cells is detected only through a microscope observation or chemical hematuria, gross hematuria is visible to the naked eye, dark urine.
Hematuria
Most of the time, microscopic hematuria does not look like blood red, and usually was brown and pungent taste. When the red blood cells in urine leukocyte excess, usually on behalf of the glomerular emergence of inflammation.
Microscopic hematuria may be watered down by the water looks like dehydration. However, the body's water shortage in the case of urine is dark yellow or orange, and microscopic hematuria partial dark green or light black. Transparent plastic cups can be more clearly distinguish microscopic hematuria and the color of dehydrated urine.
Although gross hematuria seem very serious, but patients often earlier than patients with microscopic hematuria discovered disease. Patients should be subject to regular testing, after the detection cycle gradually lengthened. Some initially has no symptoms of gross hematuria in patients may also have at least one gross hematuria incidence. Hematuria occurred, often due to respiratory tract infections, gastrointestinal infections, vigorous exercise, or vaccination, may also cause hematuria.
Hematuria, to pay attention to drink pure water to prevent the formation of blood clots cause pain. Hematuria onset of symptoms, the patient will feel very unwell. Symptom duration varies from person to person, most of them will continue for several days.
A small number of patients with pure hematuria continued. Such patients should avoid fish oil or other clotting effect of Pharmacy (including aspirin), because it will aggravate the bleeding.
Proteinuria
Proteinuria refers to the case of protein leakage into the urine. The vascular wall of the glomerular filtration rate, but the inflammation so that the filter relaxation of the vascular wall, resulting in macromolecular outflow. Glomerular charge under normal circumstances, a filter, because the basement membrane is negatively charged, while suffering from IgA nephropathy, because the release of inflammatory cells with the positively charged enzyme and the negative charge of the basement membrane, vessel wall will not be able to prevent negatively charged protein outflow.
To flush out some protein (less than 150mg / d or 0.15g / d) is normal, but beyond this value there will be problems. Proteinuria is usually as severe (greater than 3000mg / d), moderate (1000-2900mg / d) and minor (less than three levels of 1000mg / d). Some patients with IgA nephropathy, especially children, are usually mild to moderate proteinuria.
Proteinuria can be divided into "selective proteinuria (smaller molecular weight protein-based) and non-selective proteinuria (including a variety of molecular weight proteins). Generally speaking, the selectivity of proteinuria in patients, especially patients with albumin relative to single One of predictability is stronger than than the non-selective proteinuria.
One kind of hematuria, proteinuria often aggravate the disease onset, respiratory diseases, other diseases or mental stress may aggravate proteinuria symptoms.
If, during the development of IgA nephropathy, protein loss continues to be maintained at a heavier level of words, and may lead to poor prognosis. Heavy proteinuria often lead to high blood pressure sicker when protein loss excessive (more than 3g / d), may lead to nephrotic syndrome, the symptoms include edema, fatigue, loss of appetite, abdominal pain and muscle atrophy. If left untreated, a huge loss of immunoglobulins, hormones, and specific proteins will lead to malnutrition and bone demineralization, and aggravate infectious diseases likely to get sick.

Cause the causes and risk factors of IgA nephropathy

The kidney is located in the body cavity by the position of the spine on each side, one pair of watercress-like, fist-sized organ. Each kidney contains small blood Guanxi (kidney and small cones), and filter the blood of waste and excess water. The waste then flows through the bladder when you urinate excreted, then after filtering the blood to re-enter the blood stream of normal operation.
Immune cones protein A is an antibody that plays an important role in the attack invading pathogens. But which in IgA nephropathy, this antibody gathered in renal cones affect its ability to filter slowly.
The reasons of IgA nephropathy
Research scientist can not know exactly what is causing IgA deposition in the kidney, the following factors may be the development of and IgA associated with:
1, genes, IgA nephropathy is more common in some families and ethnic groups show that may be genetically related.
, Cirrhosis, scab tissue replacement normal intrahepatic organization.
3, celiac disease, digestive problems caused by eating the protein-containing cereals.
4, cell-like rash dermatitis, caused by gluten intolerance, the very fast itch skin disease.
5, infectious diseases, including the HIV epidemic and bacterial infectious diseases.
IgA nephropathy: risk factors
Do Guanxi cause is unknown, some factors increase the incidence of diseases:
1, the age, the disease will affect the population of all ages, including children, but it is more likely to occur in the teenage and 21-year-old among the crowd.
Gender, in North America and some Western European countries, the incidence of the disease men than women is higher more than twice.
, Race, compared with blacks, the disease among whites and Asians more generally.
Family history, under certain circumstances, the disease seems in the family is very popular, suggesting that genetic factors may lead to the occurrence of the disease.

The symptoms of IgA nephropathy

IgA nephropathy is a kidney disease which is too much trouble a kidney disease, it will give patients and their families a great deal of pain, therefore, to understand some of Iga nephropathy symptoms, there are still some necessary details on the prevention and treatment of Iga nephropathy we see the introduction of the expert.
Anemia
IgA nephropathy in renal failure patients have suffered damage kidney function, in which the body can not produce enough hormones required to manufacture red blood cells, resulting in anemia. IgA nephropathy in patients with renal failure anemia often feel cold and tired. This is a iga nephropathy symptoms can be seen the most direct.
Hypertension
Some patients with IgA nephropathy in renal function declining at the same time, the clinical manifestations of increase in blood pressure. High blood pressure symptoms of IgA renal failure patients, not a good thing. Hypertension may accelerate the rate of progress of deterioration of renal function of patients with IgA nephropathy, rapidly their condition to the uremic stage.
Physical discomfort
Patients with IgA nephropathy, the kidney function decline, causing the body to produce a large number of toxins and metabolic wastes continue to accumulate in the body, and IgA nephropathy patients may feel the whole body does not apply to appear such as nausea, vomiting, trouble sleeping at night, loss of appetite, a series of symptoms such as itching and fatigue.
Edema
IgA nephropathy may suffer from puffiness of the body. In addition, with the occurrence of swelling of the body, may also be associated with decreased urine output, frequent urination (especially at night) and other symptoms. IgA nephropathy edema of the performance of hand foot and ankle edema, swelling around the eyes. IgA nephropathy in patients with renal failure, shortness of breath and other phenomena may also occur.

Treatment of IgA nephropathy where to begin

IgA nephropathy is an immune the cones protein A cause of primary renal cones nephritis. According to the latest findings of the nephrologist, the treatment of IgA nephropathy is simply to repair kidney damage or anti-inflammatory. Want to get rid of from the root of IgA nephropathy, and you need a system of treatment.
Treatment of IgA nephropathy where to begin?
To answer this question, we must understand the pathogenesis of IgA nephropathy. In fact, its pathogenesis is not hard to understand. IgA nephropathy in the past was that the doctor felt difficult, because the wound did not find the root cause of IgA nephropathy - immune system defects.
IgA nephropathy in the end is how the incidence of it?
IgA, is translated into immune cones protein A, is the immune system to secrete an antibody of immunoglobulin A abbreviation. What are antibodies? Antibody and antigen relative. Refers to when the antigen, such as bacteria, viruses into the human body, the body's immune system to produce antibodies, with contravention of anti-, for the protection of human health. IgA nephropathy is caused by IgA abnormalities.
The IgA how triggered IgA nephropathy?
Under normal circumstances, when the virus attacks the body, the immune system will release the right amount of antibodies to kill the bacteria protect the body's normal operation. For patients with IgA immune system defects, their body will release excess IgA. Bacteria or IgA IgA will be the body itself will form a new substance called immune complex Hesheng matter. These immune complex Hesheng things will stay with the body's blood flow through the kidney and the kidney.
Due to the exclusivity of the body's own immune system starts the immune and inflammatory response of the kidney around to clear immune complex Hesheng matter deposition in the kidney. However, because of their immune system defects, immune complex Hesheng matter not only failed to be cleared, but the inflammatory reaction of the radical immune hurt the surrounding normal cells and tissues of the kidney, causing kidney damage, which is the pathogenesis of IgA nephropathy.
Treatment of IgA nephropathy from where to start?
The pathogenesis of IgA nephropathy, we can draw the following treatment options:
First, to clear the blood of immune complex Hesheng things, to reduce the immune complex Hesheng matter deposition in the kidney.
Second, to clear the kidney on immune complex Hesheng, to reduce the immune and inflammatory response.
Third, anti-inflammatory, to prevent extreme inflammation surrounding renal tissue injury.
Fourth, for the injured kidney tissue, we can by nourishing Qi, Jianshen raise spleen Chinese medicine to repair.
Fifth, rebuild the immune system, get rid of the root cause of IgA nephropathy, and to prevent recurrence of the disease.
Currently focuses on control of inflammation, through western medicine Hesheng matter of immune complex clearance, renal damage, repair, rebuild their immune system, the current Western medicine is "do anything" for the treatment of IgA nephropathy. This also explains the reasons for recurrent disease. The experts recommend starting treatment for kidney disease from the perspective of immunization by Western medicine, Chinese medicine and immunotherapy treatment of IgA nephropathy.