Etiology and complications of IgA nephropathy

The nephropathy pairs of lentils organ size of a fist, located on both sides of the back spine. Each kidney through the filter flows through the kidney's blood from the capillaries (glomerulus) in the waste and excess water to play a role. Blood filtered again to start a new round of blood circulation. Filter out waste as urine into the bladder and then excreted.
IgA is an immunoglobulin class of antibodies, and assume responsibility for the eradication of the antigen plays a key role in the immune system. However, it is due to the deposition of this immunoglobulin in the glomeruli, which leads to impaired kidney filtration function, which immediately caused IgA nephropathy.
After years of research, but the reasons leading to IgA deposition is still a mystery.
May result in the etiology of IgA nephropathy include:
Genetic
Certain family of multiple IgA nephropathy, and to the occurrence of IgA nephropathy and genetic relationship.
Cirrhosis of the liver
The healthy kidney tissue lesions occur in one of the scar tissue is IgA nephropathy as a causal factor
Celiac disease
Digestive diseases caused due to consumption of commonly found in the gluten proteins in grain may trigger IgA nephropathy
Dermatitis herpetiformis
A gluten intolerance accompanied by itching, blisters and symptoms of skin diseases
Infection
HIV infection and various types of viral infections
IgA nephropathy in the course of the disease varied, but also vary from person to person. Although some patients many years of illness, but stable condition, basically no complications. In fact, many times some of the symptoms is not likely to be diagnosed. In addition some patients may occur an even more complications.
Hypertension
Kidney damage caused by IgA deposition can cause elevated blood pressure. This can lead to further damage of the kidney.
Acute renal failure
Once the kidney deposition of IgA in the loss of filtration function, metabolic waste generated will be much more rapid deposition in the blood. At this point, the patient will have to dialysis treatment. After dialysis, the patient's body wastes, toxins will be excreted through the machine, which originally is the responsibility of the kidneys. Dialysis, the doctor will needle through a special access point into your arm, after the blood through the catheter into the dialysis machine. Filtered clean blood to flow back to your body will go through the other end of the catheter.
Chronic renal failure
IgA nephropathy can cause the kidneys gradually lose function. Once renal function is completely lost, and patients in order to survive only accept permanent dialysis or a kidney transplant.
Nephrotic syndrome
Nephrotic syndrome is a series of symptoms of kidney disease caused by glomerular damage. Including high proteinuria, hypoproteinemia, eyelids, feet and abdominal edema.